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Blood-brain barrier in physiology and medicine

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Published by Raven Press in New York .
Written in English


  • Blood-brain barrier.,
  • Aqueous humor.,
  • Vitreous humor.,
  • Biological transport.

Book details:

Edition Notes

StatementStanley I. Rapoport.
LC ClassificationsQP375.5 .R36
The Physical Object
Paginationxii, 316 p. :
Number of Pages316
ID Numbers
Open LibraryOL5201927M
ISBN 100890040796
LC Control Number75026280

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  For assistance, please contact: AAN Members () or () (International) Non-AAN Member subscribers () or () option 3, select 1   Download Blood Brain Barrier In Drug Discovery books, Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts Abstract. A strict regulation of the neuronal environment is essential for optimal brain function. The blood-brain barrier (BBB), a concept including the morphological and functional mechanisms that restricts or facilitates the passage of substances from blood to brain, enables the brain environment to be regulated relatively independently of fluctuations in plasma :// Disclaimer. Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety ://

  The blood brain barrier (BBB) is a selective semipermeable boundary separating the circulating blood from the brain and the extracellular fluid of the central nervous system. It restricts the diffusion of solutes in the blood and hydrophilic molecules into the CSF but allows the diffusion of hormones, oxygen, carbon dioxide and other polar +of+the+csf+and+blood+brain+barriers. Dao H. Ho, Warren W. Burggren, Blood-brain barrier function, cell viability, and gene expression of tight junction-associated proteins in the mouse are disrupted by crude oil, benzo[a]pyrene, and the dispersant COREXIT, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, /, , (), ().   Blood-brain barrier (BBB) is an anatomical gateway that is an essential requisite for maintenance of homeostasis and physiological environment of the central nervous system (CNS). It is a distinctive interface between CNS and peripheral circulation that strictly regulates the entry of specific molecules from circulation or their :// The blood-brain barrier (BBB) is the frontier that isolates brain tissues from the substances circulating in the blood vascular system. It is also a diffusion barrier that allows only water and small lipophilic molecules to freely access the brain in accordance with their concentration ://

  This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular existence of such a physical, enzymatic, and active barrier isolating the central nervous system has Blood–Brain Barrier Transport Helps to Explain Discrepancies in In Vivo Potency between Oxycodone and Morphine Anesthesiology (March ) Influence of St. John’s Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial /46/1/79//Blood-Brain-Barrier-in-Physiology-and-Medicine. "An outstanding addition to the field! The book is unique in its organization and ease of reading and use as research resource. In my view, this book will emerge as one of the more cited and critical sources of information for all researchers exploring the nature of the blood-brain barrier."-Doody's Health Science Book Review  › Books › Medical Books › Medicine.